abstract：BACKGROUND:Current mammographic technology has resulted in increased detection of ductal carcinoma in situ (DCIS). It is necessary to assess which patients presenting with DCIS are good candidates for breast conservation and which of these patients should receive adjuvant radiation. METHODS:We accrued clinical data fo...

journal_title：Annals of surgical oncology

authors： Fish EB,Chapman JA,Miller NA,Link MA,Fishell E,Wright B,McCready DR,Hiraki GY,Ross TM,Hanna WM,Lickley HL

更新日期：1998-12-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to determine whether routine biologic tumor markers can predict lymph node status. The authors attempted to discover whether predictors of axillary lymph node metastasis based on biologic characteristic of primary breast cancers exist. METHODS:Eight hundred and fifty-one patien...

journal_title：Annals of surgical oncology

authors： Velanovich V,Szymanski W

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Preoperative cutaneous lymphoscintigraphy (LS) to identify sentinel (first-tier) lymph nodes was performed in 250 consecutive melanoma patients before wide local excision only or wide local excision with sentinel node biopsy. METHODS:The location of the sentinel nodes was marked on the overlying skin in all...

journal_title：Annals of surgical oncology

authors： Uren RF,Howman-Giles RB,Thompson JF

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:The prevalence and significance of free cancer cells in the peritoneal cavity of clinically M0 gastric cancer patients is unknown. We reviewed our results with peritoneal washings to determine (1) the prevalence of positive cytology in M0 and M1 disease and (2) the influence of positive cytology on the patte...

journal_title：Annals of surgical oncology

authors： Burke EC,Karpeh MS Jr,Conlon KC,Brennan MF

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:A patient's likelihood of dying from breast cancer or another cause can be assessed with competing risks analyses. METHODS:Data for a cohort of 678 patients with primary invasive breast cancer accrued from 1971 to 1990, updated to 1995, included cause of death (e.g., breast cancer vs. other cause). We inves...

journal_title：Annals of surgical oncology

authors： Fish EB,Chapman JA,Link MA

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Although significant progress has been made in the management of children with Wilms tumor, two major controversies still exist: the extent of radiographic evaluation necessary before surgery and the role of preoperative chemotherapy. This study sought to determine whether patients with Wilms tumor who prese...

journal_title：Annals of surgical oncology

authors： Davidoff AM,Soutter AD,Shochat SJ

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Dynamic contrast-enhanced magnetic resonance imaging (MRI) of the breast is highly sensitive for the diagnosis of primary breast malignancy. We investigated the clinical application of dedicated dynamic breast MR for routine screening for local recurrence following breast-conserving therapy. METHODS:Patient...

journal_title：Annals of surgical oncology

authors： Drew PJ,Kerin MJ,Turnbull LW,Imrie M,Carleton PJ,Fox JN,Monson JR

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Health care reform places primary care (PC) physicians in an increasingly significant role for breast cancer screening and diagnosis. This study assessed the adequacy of traditional PC resident training to prepare physicians for this front-line role. METHODS:Sixty-eight primary care residents, representing ...

journal_title：Annals of surgical oncology

authors： Chalabian J,Formenti S,Russell C,Pearce J,Dunnington G

更新日期：1998-03-01 00:00:00

abstract：BACKGROUND:Debate regarding axillary dissection in the treatment of women with small invasive cancers of the breast has been increasing. Recently, omission of axillary dissection has been proposed because of the reported low incidence of nodal metastases in women with such cancers. Variation in the incidence of nodal m...

journal_title：Annals of surgical oncology

authors： Mustafa IA,Bland KI

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DC) are potent professional antigen-presenting cells that can activate naive T lymphocytes and initiate cellular immune responses. As adjuvants, DC may be useful for enhancing immunogenicity and mediating tumor regression. Endogenous expression of antigen by DC could offer the potential adva...

journal_title：Annals of surgical oncology

authors： Kim CJ,Cormier J,Roden M,Gritz L,Mazzara GP,Fetsch P,Hijazi Y,Lee KH,Rosenberg SA,Marincola FM

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Magnetic resonance cholangiopancreatography (MRCP) is a new noninvasive diagnostic method for pancreaticobiliary (PB) imaging without endoscopy, sedation, or iodinated contrast. The purpose of this study was to evaluate the ability of MRCP to depict pancreatic and biliary ductal anatomy compared to that of e...

journal_title：Annals of surgical oncology

authors： Feldman DR,Kulling DP,Kay CL,Cole DJ,Cunningham JT,Hawes RH,Tarnasky PR,Cotton PB,Baron PL

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:CA 19-9 levels are useful for the diagnosis of patients with pancreatic adenocarcinoma. However, interest has recently turned toward its use as a prognostic indicator. The purpose of this study is to determine whether postoperative CA 19-9 levels predict disease-free survival (DFS) and median survival (MS) i...

journal_title：Annals of surgical oncology

authors： Montgomery RC,Hoffman JP,Riley LB,Rogatko A,Ridge JA,Eisenberg BL

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:It has been proposed that clones of tumor cells acquire higher metastatic potential as a result of specific genetic alterations. This study was designed to determine the role of the c-met protooncogene in systemic spread by comparing the loss of the c-met protooncogene between primary and metastatic breast c...

journal_title：Annals of surgical oncology

authors： Ng EH,Pey HB,Law HY,Ng I,Ji CY,Lin V,Soo KC

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Complete resection of a retroperitoneal sarcoma often requires removal of adjacent organs. In this study we evaluated the role of nephrectomy during operation for retroperitoneal sarcoma. METHODS:Between July 1982 and July 1995, 75 of the 371 (20%) patients who underwent resection of retroperitoneal sarcoma...

journal_title：Annals of surgical oncology

authors： Russo P,Kim Y,Ravindran S,Huang W,Brennan MF

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Microsatellites are short repetitive nucleotide sequences that, through mutation, can undergo either expansion or contraction. This novel mutational mechanism known as microsatellite instability may play a role in carcinogenesis. We investigated the incidence of microsatellite instability in a series of prim...

journal_title：Annals of surgical oncology

authors： Rush EB,Calvano JE,van Zee KJ,Zelenetz AD,Borgen PI

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:To improve the poor prognosis of patients with advanced incurable gastric cancer, intensive chemotherapy combined with radical surgery was used. PATIENTS AND METHODS:Thirty patients with incurable gastric cancer were treated with a combination of 5-fluorouracil (370 mg/m2) and leucovorin (30 mg/person), giv...

journal_title：Annals of surgical oncology

authors： Nakajima T,Ota K,Ishihara S,Oyama S,Nishi M,Ohashi Y,Yanagisawa A

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:In recent years, as a result of refinement in molecular biology techniques, significant progress has been made in the understanding of colorectal carcinogenesis. Particular attention has been drawn to identification of genetic mutation that may predispose to colorectal carcinoma (familial syndromes) and may ...

journal_title：Annals of surgical oncology

authors： Pricolo VE,Finkelstein SD,Bland KI

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Tumor size can be measured easily before or during operation with no special tools, but its prognostic use in patients with gastric carcinoma is still unclear. METHODS:Clinicopathologic data of 479 patients who underwent curative operation for gastric carcinoma were studies. The relationship between tumor s...

journal_title：Annals of surgical oncology

authors： Adachi Y,Oshiro T,Mori M,Maehara Y,Sugimachi K

更新日期：1997-03-01 00:00:00

abstract：BACKGROUND:Most cytokine-based cancer gene therapy clinical trials have used labor-intensive, retrovirus-mediated strategies resulting in unpredictable gene expression. Recombinant AdV vectors were evaluated for easier, more reproducible gene transfer into 12 human melanoma, 2 murine fibrosarcomas, and 8 other tumor ce...

journal_title：Annals of surgical oncology

authors： Toloza EM,Hunt K,Miller AR,McBride W,Lau R,Swisher S,Rhoades K,Arthur J,Choi J,Chen L,Chang P,Chen A,Glaspy J,Economou JS

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Heat shock protein 27 (hsp-27) is overexpressed in approximately 67% pure ductal carcinoma in situ (DCIS), in approximately 50% DCIS associated with invasive ductal carcinoma (IDC), and in approximately 25% IDC alone. If this decrease in hsp-27 expression has a role in the progression of malignancy in IDC, w...

journal_title：Annals of surgical oncology

authors： Storm FK,Mahvi DM,Gilchrist KW

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Recently, ultrasound (US)-guided needle biopsy has been proposed as an acceptable alternative to open biopsy in women with nonpalpable breast masses. This study evaluated the accuracy of US-guided needle biopsy of nonpalpable breast masses performed by surgeons at the time of the initial clinical examination...

journal_title：Annals of surgical oncology

authors： Staren ED

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:The management of state III breast cancer is challenging; it often includes multimodal treatment with systemic therapy and/or radiation therapy and surgery. Immediate breast reconstruction has not traditionally been performed in these patients. We review the results of immediate transverse rectus abdominis m...

journal_title：Annals of surgical oncology

authors： Styblo TM,Lewis MM,Carlson GW,Murray DR,Wood WC,Lawson D,Landry J,Hughes L,Nahai F,Bostwick J 3rd

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:There is a continuous interest in the literature concerning the management and survival after treatment of local recurrence in sarcomas because it is one of the most common types of recurrence. DESIGN:We retrospectively reviewed 93 patients treated for local recurrence from soft-tissue sarcoma. METHODS:We ...

journal_title：Annals of surgical oncology

authors： Karakousis CP,Proimakis C,Rao U,Velez AF,Driscoll DL

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Brain metastases account for 20-54% of reported deaths from melanoma. Duration and quality of survival depend on the extent of metastatic disease and response to treatment. Treatment goals are palliation of symptoms and prolongation of life. No studies have directly compared surgery alone and surgery with ad...

journal_title：Annals of surgical oncology

authors： Skibber JM,Soong SJ,Austin L,Balch CM,Sawaya RE

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:The increasing use of mammography has led to a significant increase in the detection of clinically occult lesions, the majority of which prove to be benign. SFNB has been suggested as a means of expediting a diagnosis for lesions that are malignant while limiting surgical biopsies for those that are benign. ...

journal_title：Annals of surgical oncology

authors： Mitnick JS,Vazquez MF,Pressman PI,Harris MN,Roses DF

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:In patients with colorectal hepatic metastases, response rates with hepatic arterial infusion (HAI) FUdR (5-Fluoro-2-deoxyuridine) are significantly higher than with systemic fluoropyrimidines. We report a novel animal model of intrahepatic therapy for hepatic metastasis for the study of methods to increase ...

journal_title：Annals of surgical oncology

authors： Sutanto-Ward E,Arisawa Y,Tremiterra S,Sigurdson ER

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:The FAK gene encodes a 125-kDa tyrosine kinase (p125FAK) involved in signal transduction pathways used in cell adhesion, motility, and anchorage-independent growth. Because thyroid carcinomas have a wide variability in their propensity for invasion and metastasis, we studied the expression of FAK in a variet...

journal_title：Annals of surgical oncology

authors： Owens LV,Xu L,Dent GA,Yang X,Sturge GC,Craven RJ,Cance WG

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:The anti-tumor effects of three mouse mammary tumors transfected to express interleukin (IL) 2 or 4 were evaluated. METHODS:Three immunologically different tumors were used: DA3, EMT6, and 410. All three cell lines were successfully transfected using high efficiency viral vectors. Wild-type or transfected t...

journal_title：Annals of surgical oncology

authors： Matory YL,Chen M,Goedegebuure PS,Eberlein TJ

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Many invasive breast cancers are accompanied by a variety of noninvasive components. Histological distinctions have been made between these components, but to understand their importance, it is essential to examine their molecular biology. METHODS:Proliferative indices, oncoproteins, and steroid receptor ex...

journal_title：Annals of surgical oncology

authors： Brower ST,Ahmed S,Tartter PI,Bleiweiss I,Amberson JB

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Nonpalpable breast lesions are being detected with increasing frequency with the advent of improved mammographic techniques. Although only 20-30% of these lesions are malignant, definitive diagnosis has usually required a needle-localization excisional biopsy, which is costly and increases the psychological ...

journal_title：Annals of surgical oncology

authors： Meterissian S,Fornage BD,Singletary SE

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Tumor growth and metastases require the development of new vessels (angiogenesis). Angiogenesis, assessed by microvessel count using immunocytochemical stain of endothelial cells, has been shown to predict metastases and correlate with early death. Recently developed color Doppler mapping can detect the "tum...

journal_title：Annals of surgical oncology

authors： Lee WJ,Chu JS,Houng SJ,Chung MF,Wang SM,Chen KM

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Radionuclide scans that use Tc-99m-pertechnetate or I-123 currently lack the specificity to assess the malignant potential of solitary solid lesions of the thyroid gland. Tc-99m-sestamibi scanning was used to determine the neoplastic potential of thyroid lesions. METHODS:Patients with lesions of the thyroid...

journal_title：Annals of surgical oncology

authors： Wei JP,Burke GJ

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:Malignant pleural effusions are seen frequently in clinical practice and are most commonly caused by breast cancer and lung cancer. Standard treatment usually consists of complete drainage of the pleural space via a chest tube and instillation of a pleural irritant to obtain pleural symphysis. In a majority ...

journal_title：Annals of surgical oncology

authors： Fry WA,Khandekar JD

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Primary gastrointestinal sarcomas are uncommon, and the clinicopathological determinants of survival remain unclear. In order to correlate clinical presentation, pathological assessment, and treatment with outcome, we have analyzed our institution's recent experience with these tumors. METHODS:Records of ad...

journal_title：Annals of surgical oncology

authors： Conlon KC,Casper ES,Brennan MF

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Women with breast cancer treated by mastectomy with immediate breast reconstruction can get exceptionally good results if the reconstruction is performed with autogenous tissue using the transverse rectus abdominis myocutaneous (TRAM) flap. Bilateral reconstruction with TRAM flaps is also possible, but only ...

journal_title：Annals of surgical oncology

authors： Kroll SS,Miller MJ,Schusterman MA,Reece GP,Singletary SE,Ames F

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:We performed a phase I study of a novel system of complete hepatic venous isolation and extracorporeal chemofiltration in patients with unresectable hepatocellular carcinoma (HCC) to determine (a) whether systemic exposure to doxorubicin could be limited after high-dose hepatic arterial infusion (HAI), and (...

journal_title：Annals of surgical oncology

authors： Curley SA,Newman RA,Dougherty TB,Fuhrman GM,Stone DL,Mikolajek JA,Guercio S,Guercio A,Carrasco CH,Kuo MT

更新日期：1994-09-01 00:00:00

abstract：METHODS:This study evaluated the effectiveness and morbidity associated with 116 peritoneovenous shunts inserted into 89 patients for symptomatic malignant ascites between 1981 and 1991. All patients had previously failed standard medical therapy of salt and fluid restriction, diuretics, and intermittent peritoneal asp...

journal_title：Annals of surgical oncology

authors： Schumacher DL,Saclarides TJ,Staren ED

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:The relative effects of growth hormone on tumor versus host growth and protein metabolism are not known. This study examines the influence of recombinant rat growth hormone (r-rGH) on host and tumor growth, host body composition, and protein synthesis of tumor and host in tumor-bearing rats. METHODS:After l...

journal_title：Annals of surgical oncology

authors： Wolf RF,Ng B,Weksler B,Burt M,Brennan MF

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:We sought to determine the competence of medical students and surgery residents in evaluating clinical problems (using both real and simulated patients) in surgical oncology. METHODS:Forty-five third-year medical students, 23 first postgraduate year (PGY-1) residents, and seven second postgraduate year (PGY...

journal_title：Annals of surgical oncology

authors： Sloan DA,Donnelly MB,Schwartz RW,Munch LC,Wells MD,Johnson SB,Strodel WE

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Arginine plays a pivotal role in regulating ureagenesis, polyamine biosynthesis, and nitric oxide production, metabolic pathways that may be stimulated in the liver of the tumor-bearing host. Normally, plasma arginine is excluded from the hepatocyte intracellular space by the low basal activity of its membra...

journal_title：Annals of surgical oncology

authors： Espat NJ,Copeland EM,Souba WW

更新日期：1994-03-01 00:00:00